Global Burden of Disease Study 2021 (GBD 2021) - Cause of Death 4 (Encephalitis - Human African Trypanosomiasis (HAT))

Encephalitis

• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction
• Standardize input data

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Endocarditis

• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction
• Standardize input data

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Endocrine, metabolic, blood, and immune disorders

• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction
• Standardize input data

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Epilepsy

• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction
• Standardize input data

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Fatal Discontinuities

• Cause Mapping
• Location Mapping
• Year Splitting
• Side Splitting
• Identify Shock's location cause years
• Extract Shock Deaths from CoD VR
• Outlier Removed VR points in CoD Database
• Prioritization
• Age sex splitting
• Generate Uncertainty
• Run Draws
• Combine Fatal Discontinuity Estimates with CODEm models
• Aggregate results to the all cause - World estimates

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Gallbladder and biliary diseases

• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction
• Standardize input data

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Gastritis and duodenitis

• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction
• Standardize input data

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GBD Cause of death & COVID Impacts

• cause specific scalars: LRI
• cause specific scalars: pertussis
• cause specific scalars: measles

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GBD 2021 Causes of death estimation flowchart by modeling group

• Imported cases
• CODEm
• CoDCorrect
• Add imported cases, fatal discontinuities, and HIV\AIDs
• Excess mortality estimation
• DisMod-MR2.1

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Gynecological conditions

• Standardize input data
• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction

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Hemoglobinopathies and hemolytic anemias

• Cause of death estimation
  • Age sex splitting
  • CodCorrect
  • CODEm
  • Garbage code redistribution
  • ICD Mapping
  • Noise reduction
  • Standardize Input Data
  • CSMR summed and scaled to split parent COD model
• Nonfatal cause estimation
  • Dismod-MR 2.1
  • Inpatient vs. outpatient adjustment
  • Primary code adjustment from Marketscan

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Hepatitis

• Age sex splitting
• CodCorrect
• CODEm
• Garbage code redistribution
• ICD mapping
• Noise reduction
• Standardize input data

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HIV\AIDS

• 1ab. Generalized epidemics
  • EPP-ASM
  • On\Off ART models
  • (Preliminary) Spectrum
  • (Final) Spectrum
• 2ab. Concentrated epidemics with vital statistics
  • Cohort Incidence Bias Adjustment
  • ST-GPR & ST-GPR substitution
• 2c. Concentrated epidemics w\o vital statistics
  • Sample from 2A and 2B incidence adjustment

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Human African Trypanosomiasis (HAT)

• Cause of death estimation
  • Age-splitting
  • Case detection rate
  • Deaths (not age-specific)
  • Deaths among treated
  • Fill in gaps - reported coverage
  • Fill in gaps - screening coverage
  • Regression
  • Undetected cases
• Nonfatal health outcome estimation
  • Age-splitting
  • Comorbidity correction
  • Incident cases
  • Prevalence estimation
  • Splitting sleeping disorder\disfig
  • Splitting treated\untreated
  • YLD Calculation

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