Global Burden of Disease Study 2019 (GBD 2019) - Nonfatal Health Outcomes 11 (Outpatient - Pyoderma)

Outpatient

• Outpatient pipeline
  • Format and standardize ICD codes
  • Map to ICG
  • Map to bundle
  • Aggregate parent causes for injuries
  • Apply Marketscan correction factors to outpatient data
  • Apply age/sex restrictions
• Outpatient CF
  • Format and standardize ICD codes
  • Calculate prevalence and incidence correction factors

---

Pancreatitis

• 1. Nonfatal health outcome estimation for pancreatitis, acute episodes
  • Adjustment from primary code to all code based on claims data
  • Age-pattern analysis
  • Age-sex splitting
  • Comorbidity correction (COMO)
  • Dismod-MR 2.1
  • Meta-analysis
  • MR-BRT bias correction analysis for altenrative case definition/method
  • MR-BRT sex ratio analysis
  • Severity splits
• 2. Nonfatal health outcome estimation for chronic pancreatitis
  • Adjustment from primary code to all code based on claims data
  • Age-pattern analysis
  • Age-sex splitting
  • Comorbidity correction (COMO)
  • DisMod-MR 2.1
  • Meta-analysis
  • Model excess mortality in MR-BRT
  • MR-BRT bias correction analysis for altenrative case definition/method
  • MR-BRT sex ratio analysis
  • Severity splits

---

Paralytic ileus and intestinal obstruction

• Adjustment from primary code to all code for both inpatient and outpatient encounters based on claims data
• Comorbidity correction (COMO)
• DisMod-MR 2.1
• Model excess mortality in MR-BRT
• MR-BRT bias correction analysis for altenrative case definition/method

---

Parkinson Disease

• Age-pattern analysis
• Age-sex splitting
• MR-BRT bias correction analysis for Alternative Case Defintion / Method
• CODEm (model 1)
• CODEm (model 2)
• Comorbidity correction (COMO)
• Dismod-MR 2.1 (model 1)
• Dismod-MR 2.1 (model 2)
• Dismod-MR 2.1 (model 3)
• EMR regression using countries with highest CSMR to prevalence ratios
• Select countries with the highest CSMR\ prevalence ratios
• Garbage code redistribution
• ICD mapping
• Meta-analysis of % mild, moderate, severe Parkinson's
• Noise reduction
• Severity splits
• Standardize input data
• Multiple Cause of Death data analysis
• Parkinson's disease redistribution

---

Pelvic Inflammatory Disease

• Adjustment from primary code to all code for both inpatient and outpatient encounters based on claims data
• Dismod-MR 2.1
• Split PID parent model
• Severity Splits
• Comorbidity correction (COMO)

---

Peptic Ulcer Disease

• 1. Nonfatal health outcome estimation
  • Format codes, Map to modeling causes
  • Convert claims to cases, Apply duration window, Apply age and sex restrictions, Aggregate
  • Calculate 3 correction factors
  • Convert inpatient encounters to incident or prevalent cases (+/- Adjust: primary dx -> any inpatient -> any), Apply age and sex restrictions, Aggregate
  • Model excess mortality in MR-BRT
  • DisMod-MR 2.1
  • Comorbidity correction (COMO)
• 1. Nonfatal health outcomes estimation
  • Bias adjustment for non-reference data collection in MR-BRT
• 2. Anemia estimation
  • Anemia causal attribution
• 3. Severity and anemia split
  • Proportion split
  • Subtract complicated and acute
  • Split 5 outcomes by 4 anemia proportions

---

Peripheral Arterial Disease

• Age sex splitting, bias adjustment
• Age sex splitting
• Comorbidity correction (COMO)
• Disability weights for each sequela
• DisMod-MR 2.1
• Split overall prevalence by proportion

---

Pneumoconiosis

• Geographic exclusions
• Meta-analysis of mild, moderate, severe
• Severity splits
• Comorbidity correction (COMO)
• Computing excess mortality
• DisMod-MR 2.1

---

Polycystic ovarian syndrome

• Adjustment from primary code to all code based on Claims data
• Comorbidity correction (COMO)
• Dismod-MR 2.1
• Age and sex split
• Crosswalks
• Meta-analysis of % mild, moderate, severe PCOS
• Severity splits

---

Premenstrual syndrome

• Adjustment from primary code to all code based on Claims data
• Comorbidity correction (COMO)
• Pregnancy adjustment
• Dismod-MR 2.1
• Age and sex split
• Crosswalks

---

Protein-energy malnutrition

• Proportion of children with edema & weight-for-age z-score
• DisMod: Single parameter proportion model
• Subtract proportion of edema among WHZ
• Calculate weight-for-age (WHZ) z-score using WHO Growth Standards (2006)
• Collapse into geography-year-age-sex proportion of WHZ
• Proportion of children under 5 with WHZ
• ST-GPR
• Subtract prevalence of WHZ
• Multiply prevalence of WHZ
• DisMod: Full paramter model (WHZ
• Multiply prevalence of WHZ
• Zero out prevalence of population over 5 years old
• Subtract from the prevalence of WHZ
• Scale prevalence to equal prevalence from full parameter model for >5 years (
• Apply ratio to prevalence to calculate incidence
• Comorbidity correction (COMO)

---

Pruritus

• Age-sex splitting
• Comorbidity correction (COMO)
• Dismod-MR 2.1

---

Psoriasis

• Format codes, Map to modeling causes
• Apply age and sex restrictions, Aggregate and apply population denominator
• Convert claims to prevalent cases
• Comorbidity correction (COMO)
• Dismod-MR 2.1
• Severity splits

---

Pyoderma

• Adjustment from primary code to all code based on Claims data
• Age-sex splitting
• Comorbidity correction (COMO)
• Dismod-MR 2.1

---