Marketscan claims
- Format and standardize ICD codes
- Map and aggregate to modeling causes
- Convert claims to estimates for individual encounters using a duration window
- Process inpatient and outpatient data
- Process inpatient dat
- Aggregate data into 5 year age groups
- Noise reduction
Maternal disorders
- Claims data code adjustment
- Comorbidity correction (COMO)
- All data extracted w\ live births as denominator
- Apply standard duration & severity splits
- Divide by ASFR
- Meta-analyses of mild, moderate, severe
- Multiply by ASFR
- Number of abortions per live birth
- DisMod-MR 2.1
Measles
- Comorbidity correction (COMO)
- Age sex splitting
- Mixed effects regression
- Prevalence = incidence * duration
- Severity splits
Meningitis
- Centrak severity splits
- Central squeeze
- Claims data code adjustment
- Comorbidity correction (COMO)
- Apply etiology specific cause fractions
- Apply proportion of long-term outcome
- Apply proportion of long-term outcome type
- Apply proportion of sequelae type
- Apply ratio of viral to bacterial meningitis
- Calculate EMR
- Etiology fraction estimation: Cause fraction estimations
- Etiology fraction estimation: Scale cause fractions to sum to one
- Extract ratio of viral to bacterial meningitis
- Incidence cumulative added to subseqent age
- Meta analysis of SMR
- Proportions of long-term outcome type
- Proportions of sequelae given long-term outcome
- Regression of ln(GDP) and proportion
- DisMod-MR 2.1
- Epilepsy envelope squeeze
- Etiology fraction estimation: DisMod MR
Motor neuron disease
- Comorbidity correction (COMO)
- Age-sex splitting and Age-splitting
- Meta-analysis of % mild, moderate, severe motor neuron disease
- Dismod-MR 2.1
- Severity splits
Multiple Sclerosis
- Comorbidity correction (COMO)
- Meta-analysis of % mild, moderate, severe Multiple Sclerosis
- Age-sex splitting and Age-splitting
- DisMod-MR 2.1
- Severity splits
Neck pain
- Comorbidity correction (COMO)
- DisMod-MR 2.1
- Age-sex splitting
- Map SF-12 to GBD disability weights
- Regression to estimate disability weight by cause in survey respondents controlling for comorbidity
- Severity splits
Neonatal Encephalopathy
- Comorbidity correction (COMO)
- Convert CFR to EMR
- Interpolate prevalence at 28 days
- Mixed-effects regression
- Severity split (asymptomatic, mild, moderate)
- DisMod-MR 2.1
- Severity splits
Neonatal encephalopathy
Neonatal preterm birth
- Comorbidity correction (COMO)
- Convert CFR to EMR
- Mixed-effects regression
- Severity split (asymptomatic, mild, moderate)
- SMR to EMR
- Retinopathy of prematurity
- Retinopathy of prematurity scalar regressions
- DisMod-MR 2.1
- Dismod-MR 2.1
- Severity splits
Neonatal sepsis
- Comorbidity correction (COMO)
- Convert CFR to EMR
- Interpolate prevalence at 28 days
- Meta-analysis of mild, moderate, severe
- Severity split (asymptomatic, mild, moderate)
- SMR to EMR
- DisMod-MR 2.1
- Severity splits
Non-alcoholic fatty liver disease\Non-alcoholic steatohepatitis (NFLP\NASH)
Non-melanoma skin cancer (basal cell and squamous cell carcinoma)
- Comorbidity correction (COMO)
- Mapped duration of BCC\SCC between 1-5 years based on ATC
- Split C44 into basal cell and squamous cell carcinoma based on proportion from literature
- Dismod-MR 2.1
- Severity split into 3 levels using MEPs
Non-rheumatic calcific aortic valve disease
- Age-sex splitting
- Comorbidity correction (COMO)
- Disability weights for each sequela
- Dismod MR 2.1
- Asymptomatic proportion model
- Treatment proportion model
- Heart failure severity split model
- Severity split
Non-rheumatic degenerative mitral valve disease
- Age-sex splitting
- Comorbidity correction (COMO)
- Disability weights for each sequela
- Dismod MR 2.1
- Asymptomatic proportion model
- Treatment proportion model
- Heart failure severity split model
- Severity split
