This dataset contains estimates of the period lifetime probability of HIV acquisition, which quantifies the hypothetical probability of acquiring HIV for a “synthetic cohort”, a simulated population that is aged from birth to death through the set of age-specific incidence rates of a given time period. Using GBD 2021 HIV estimates, the prevalence of unsuppressed viraemia (PUV), which represents the proportion of the population without a suppressed level of HIV (viral load <1000 copies/mL) was also estimated. Forecasts for mortality, prevalence, and incidence through 2050 were also created.