Researchers systematically reviewed, identified, and extracted data from cohort, case-control, and Mendelian randomization studies published between 1970 and 2021 that estimated the association between alcohol consumption and risk of ischemic heart disease. In total, 124 unique studies were included. Relative risk curves for the association between alcohol consumption and ischemic heart disease were estimated using data from cohort and case-control studies separately and in combination, and from Mendelian randomization studies using the Burden of Proof meta-analytic framework.