This dataset includes total cardiovascular disease burden estimates globally for multiple cardiovascular diseases for 7 Global Burden of Disease Study (GBD) super regions, 21 GBD regions, 204 countries and territories, and select subnational locations. The following are reported: mortality by age and sex for the years 1990 and 2021; age-standardized mortality in 2021 by Socio-Demographic Index (SDI), a composite indicator of fertility, income, and education; all ages and age-standardized prevalence for 2021; and age-standardized disability-adjusted life years (DALYs) for 2021. The dataset also includes burden attributable to selected risk factors for each GBD region in 2021, as measured by DALYs. These data are custom calculated for publication in the Journal of the American College of Cardiology and will not be available in the GBD 2021 Results Tool.