As part of an analysis on the effects of the COVID-19 pandemic on gender equality, researchers at IHME reviewed publicly available datasets with information related to: vaccine hesitancy and uptake; healthcare services; economic and work-related concerns; education; and safety at home and in the community. Estimates of the prevalence of impacts of the COVID-19 pandemic on the domains listed above were produced by gender and world region using data from 13 sources with sex- or gender- disaggregated data. One additional gender-invariant source was used in estimating vaccine uptake. This dataset provides the generated estimates by gender and seven world regions (North Africa and Middle East; Sub-Saharan Africa; Central Europe, Eastern Europe, and Central Asia; High-income; South Asia; Latin America and Caribbean; and Southeast Asia, East Asia, and Oceania). This dataset also provides estimates by month (March 2020 – September 2021), when available.