This dataset is the result of a study to quantify health-care spending attributable to modifiable risk factors in the United States of America for 2016. Data from two existing studies were used to produce the estimates. The first dataset is the Institute for Health Metrics and Evaluation’s Disease Expenditure Study 2016, from which estimates of US health-care spending by condition, age, and sex were extracted. These results were merged with population attributable fraction estimates for 84 modifiable risk factors from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. Estimates were produced for spending by 14 aggregate conditions attributable to 19 risk factors. The estimates are by sex and 5 age groups and reported in 2016 US dollars.