IHME researchers conducted a systematic review of published literature containing data on onchocerciasis-related infection and disability indicators from 1975-2017, encompassing the period of implementation for control and local elimination programs among the Americas, Africa and Yemen. Ultimately, geographic data, as well as relevant epidemiological metadata, were extracted from 259 peer-reviewed sources reporting prevalence of onchocerciasis. This dataset contains the following: a screening sheet detailing all studies reviewed; a database of onchocerciasis prevalence containing 14,043 unique location, diagnostic, age and sex-specific records marked for collapse where a single geo-position is shared between multiple records; and a conversion file that connects the names of diagnostics extracted and standardized during the review to diagnostic codes and diagnostic groups.