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United States Osteoarthritis Initiative, A Knee Health Study


General Info
Coverage type 
Time period covered 
02/2004 - present
Series or system 
United States Osteoarthritis Initiative, A Knee Health Study
Data type
Intervention study:
  • Exam
  • Individual
  • Interview
  • Longitudinal

The United States Osteoarthritis Initiative, A Knee Health Study (OAI) is a longitudinal clinical trial that provides information on the progression of knee osteoarthritis in 4,796 men and women age 45-79. Participants of OAI were enrolled at four clinical centers in the United States between February 2004 and May 2006. The criteria for inclusion in the OAI study were persons who had symptomatic knee osteoarthritis at the time of enrollment, or who were at risk of developing the condition. 

OAI questionnaire measures included: SF-12 general health, demographics, employment, health care use, knee symptoms, daily activities and physical function, development of and current disability, medication, health behaviors, and osteoarthritis risk factors.

OAI exam measures included: Blood and urine collection, anthropometry, hand and knee examinations, blood pressure and heart rate readings, MRI, X-ray, DXA (bone mineral density), and physical activity performance measures.

Suggested citation 
Brown University, Johns Hopkins University, Memorial Hospital of Rhode Island, Ohio State University, Osteoarthritis Initiative, University of California San Francisco, University of Maryland, University of Pittsburgh. United States Osteoarthritis Initiative, A Knee Health Study. San Francisco, CA, United States: University of California San Francisco.