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## Lead Exposure

- Age-sex splitting
- Application of mediation factors
- Bradmod
- Calculate CLBI
- Calculate shift in IQ
- Calculate shift in SBP
- Crosswalk lead to geometric means
- ST-GPR
- TMREL

## Low glomerular filtration rate

## Occupational Exposures

- Combine economically active pop with industry %
- Combine with exposure data
- Crosswalk using mixed effect model
- Scale GPR category outputs to 1
- ST-GPR

## Physical Inactivity

- Application of mediation factors
- Apply a percentile value to each MET-minute/week category
- Bayesian regressions (BradMod)
- Calculate PAFs
- Calculate proportion in each activity level
- Convert frequency, intensity, and duration to MET-minutes per week
- Dismod-MR 2.1
- Map percentiles from relative risk studies
- Rescale proportion models to sum to 1
- Run log-log ordinary least squares regression
- Two pre-DisMod crosswalks

## Radon Exposure

- Application of mediation factors
- Calculate PAFs
- Calculate relative risk
- Crosswalk radon to geometric means
- ST-GPR
- TMREL

## Second-hand Smoke

- Adjustment of denominator from non-smokers to general pop
- Application of mediation factors
- Bayesian MCMC nonlinear curve-fitting
- Calculate PAFs
- Crosswalk estimates from surveys
- Dismod-MR 2.1
- IER
- Literature review

## Smoking

- Age-sex splitting
- Application of mediation factors
- Calculate PAFs
- Cross-walk between different definitions
- Meta-analysis of relative risks
- SIR
- ST-GPR
- TMREL

## Spatiotemporal Gaussian Process Regression

- Aggregate subnational estimates and replace national estimates
- Cross-Validation
- Data Processing
- Gaussian Process Regression
- Linear Model
- Register model
- Rescale subnational to be consistent with national estimates
- Risk-specific post-processing
- Spatiotemporal smooting
- Upload data

## Suboptimal Breastfeeding

- Application of mediation factors
- Discontinued regional RR adjustments
- Non-exclusive regional RR adjustments
- Rescale non-exclusive categories
- Scale to proportion of ABF
- ST-GPR

## Unsafe Drinking Water

- Calculate PAFs
- Household water treatment proportions generated
- Meta-analysis of relative risks
- Remaining water categories calculated and scaled to 1
- ST-GPR
- TMREL
- Water source estimates generated

## Unsafe Handwashing

- Calculate PAFs
- Estimates from the two models multiplied together
- Meta-analysis of relative risks
- ST-GPR
- TMREL
- Two handwashing estimates generated

## Unsafe Sanitation

- Calculate PAFs
- Meta-analysis of relative risks
- Remaining sanitation category is estimated
- ST-GPR
- TMREL
- Two sanitation estimates generated

## Unsafe Sex

- Application of mediation factors
- Dismod-MR 2.1
- Extract proportion of attributable HIV cases
- Squeeze three DisMod models to sum to 1

## Zinc deficiency

- Adjust for country background deficiency
- Application of mediation factors
- Calculate PAFs
- EAR cut-point method
- Estimate total zinc content in avg diet
- Estimate zinc absorption in avg diet
- Linear regression
- TMREL