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Global Burden of Disease Study 2015 (GBD 2015) Nonfatal Code (1)

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Analytical flowchart for the estimation of cause-specific YLDs by location, age, sex, and year for GBD 2015


Acne vulgaris


Acute Endocarditis


Acute glomerulonephritis


Acute Hep A


Acute Hep B


Acute Hep C


Acute Hep E


Acute Myocarditis


Acute Urolithiasis


Alcohol dependence


Alopecia areata


Alzheimer disease and other dementias


Amphetamine use disorders


Anemia

  • Average Hemoglobin decrement ("shift") caused by each etiology
  • Bayesian contingency table modeling of etiology and severity-specific prevalence
  • Calculate 95%-ile of all country-years by age and sex = "Normal" hemoglobin
  • Calculate counterfactual hemoglobin shift removing all causes except IDA
  • Calculate difference between predicted and normal hemoglobin for each country-year-age-sex = TOTAL hemoglobin shift
  • Cause-specific hemoglobin shift
  • Comorbidity correction (COMO)
  • Divide TOTAL anemia proportionally to each cause based on the proportion of total shift attributable to that cause
  • Fit Weibull distribution by age, sex, and pregnancy status
  • Fixed effects regression of mean HgB vs. shape/scale parameters from Weibull fits
  • Predict shape/scale for all locations
  • ST-GPR, fixed effects on age in five separate models: children (males; females), adult males, adult females (pregnant; non-preg)
  • Use WHO thresholds, mean hemoglobin, and distributions to estimate prevalence (area-under-curve)

Anorexia nervosa


Anxiety disorders


Appendicitis


Ascariasis


Asperger syndrome and other autistic spectrum disorders


Asthma